25 May 2026

How does the City of Hope hospital in Los Angeles operate?

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City of Hope is one of the world’s most influential treatment and research facilities dedicated to fighting cancer and other life-threatening diseases. Despite the fact that the medical institution has been in operation for more than a century, doctors continue to develop and adjust treatment methods and techniques. Learn more about the free health management program Healthy Way LA. Find out more at i-los-angeles.

History of the medical institution’s activities

In 1913, tuberculosis killed approximately 150,000 people, more than twice the number of cancer fatalities. A group of dedicated volunteers refused to accept the tragedy, forming the Jewish Consumptive Relief Association. It was a free, non-confessional tuberculosis sanatorium. Following many fundraising activities, the Association made a down payment on 10 acres of land in Duarte, California, on which they established the Los Angeles sanitarium a year later. The sanatorium was made up of two cottages.

By the mid-1940s, the discovery and application of antibiotics had reduced the number of tuberculosis cases in the United States. However, there was no time to celebrate. Doctors at City of Hope have concentrated on humanity’s next major medical challenge: the fight against cancer. They also assisted people with diabetes and HIV/AIDS. Over the decades, hospital-based research has made substantial contributions to modern medicine. This includes the development of the first synthetic human insulin, the human growth hormone and the technology used to produce the cancer-fighting medications Herceptin, Rituxan, Erbitux and Avastin. City of Hope, which gained the NCI designation in 1981 and the status of a comprehensive cancer center in 1998, is a center for biomedical research, treatment and education. More than 200 physicians and scientists are working together to create novel disease control measures. They aim to understand the biological principles underlying cancer genesis and progression, create new treatments, test them in clinical trials and provide the best possible patient care. They also support patients and their families. This work contributes to a better knowledge of cancer risk assessment and prevention. Recombinant DNA technology and monoclonal antibodies are two examples of fundamental research results developed at City of Hope, which have since been implemented in therapy.

City of Hope is recognized by the National Cancer Institute as a comprehensive cancer center. This is the highest recognition given by the National Cancer Institute. In addition, the hospital founded the National Comprehensive Cancer Network, which provides disease research and treatment protocols. Researchers, doctors, nurses and other workers at City of Hope have made hope a reality for countless patients and their loved ones.

Areas of research at the hospital

The hospital is known as City of Hope National Medical Center, and it includes the Beckman Research Institute, the City of Hope Medical Foundation and the Irell & Manella Graduate School of Biological Sciences. 

The hospital’s research focuses on three main areas. The Biology of Cancer Program conducts fundamental laboratory research, contributing to an understanding of the basic genetic, molecular and biological origins of cancer. The clinical and translational research areas at City of Hope include developmental cancer therapy, cancer immunotherapy and hematological malignancies. These initiatives transform laboratory findings into patient care.

The third area covers the hospital’s Cancer and Population Sciences Program. It encompasses a wide range of disciplines and is enhanced by collaboration with research doctors. The program focuses on four areas: 

  • cancer determinants
  • health and quality of life following cancer treatment
  • interventional studies to reduce morbidity
  • educational programs.

Researchers from numerous research centers cooperate with City of Hope specialists, which yields positive results. The flow of research is circular, progressing from prevention and basic discovery to treatment. These studies are frequently related to Phase I and II clinical research. They are also involved in ongoing studies on survival and symptom management. City of Hope cooperates with a number of other institutions through the National Comprehensive Cancer Network, the National Bone Marrow Transplantation Research Network, the Radiation Therapy Oncology Group, the Southwest Oncology Group, the Clinical Research Consortium, the American College of Surgeons Oncology Group and the Pediatric Oncology Group.

OurHope Program

The medical facility offers a range of patient treatments both in the hospital and on its information platforms. The hospital team also contributes to the search for innovative ways of treating diseases. Thanks to modern technologies and scientific advancements, doctors now know more about cancer detection and treatment than ever before.

Participation of all stakeholders is an essential component in the creation of the OurHope Program. City of Hope Hospital reached out to team members around the company to assist patients in adapting to the changes. Meetings were held with different groups. Doctors communicated directly with patients about the initiative. Team members can provide more details about the OurHope Program when a patient approaches their doctor or nurse to share their story and express a desire to help others. City of Hope is taking bold leaps in research and therapy thanks to its innovative Classy fundraising platform. The OurHope Program helps the hospital fund breakthroughs in various kinds of cancers.

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